Evolution of HLA-DRB Genes

Mhc-DRB genes of the pigtail macaque (Macaca nemestrina): implications for the evolution of human DRB genes.

The DRB family of human class II major histocompatibility complex (Mhc) loci is unusual in that individuals differ in the number and combination of genes (haplotypes) they carry. Indications are that both the allelic and haplotype polymorphisms of the DRB loci predate speciation. Searching for the evolutionary origins of these polymorphisms, we have sequenced five DRB clones isolated from a cDN...

Associations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis.

OBJECTIVE To evaluate the clinical usefulness of genomic HLA typing during the first five years of established rheumatoid arthritis (RA). METHODS The HLA-DRB and -DQB alleles were determined by restriction length polymorphisms and polymerase chain reaction amplification with sequence specific primers in 99 Swedish patients with RA. Clinical features after two and five years disease duration w...

Mechanism of HLA Diversification Uncover Interlineage Recombinations as a The Noncoding Regions of HLA-DRB

The noncoding regions of HLA-DRB uncover interlineage recombinations as a mechanism of HLA diversification.

The mechanisms generating new alleles at the MHC loci are still unknown in detail, and several proposals have been made to explain the extent of polymorphism. The patchwork pattern of polymorphism in the 2nd exon of HLA-DRB1 recommends this locus as a model for the study of the potential of interallelic gene conversion. In general, the inference of gene conversion-like events based exclusively ...

مطالعه وابستگی الل‌های ژن‌های HLA-class II ((HLA-DRB/DQA1/DQB1 و سرطان پستان

Background: Based on the reports, high frequency of special alleles of HLA class II genes might be associated with susceptibility to or protective from a particular cancer. These alleles might vary depending on the geographical region. Here we investigate the association between alleles of HLA class II genes and breast cancer in Iranian women.Methods: 100 patients with pathologically proved bre...